Nasal spray delivery offers an appealing alternative, allowing peptides to absorb through nasal mucosa directly into systemic circulation while bypassing first-pass liver metabolism that destroys orally-administered peptides
it speaks to the larger conversation around optimizing our health while managing necessary medical treatments
In addition to reducing or eliminating the symptoms of B12 deficiency, research suggests that B12 shots may: Reduce stress (7) Support central nervous system function, red blood cell formation, and DNA synthesis (2) Reduce the risk of vision loss from age-related macular degeneration (8) Lower homocysteine levels, which is associated with cardiovascular disease and stroke (9, 10)
A few commenters highlighted that the impact of the proposed quartile-based 1-star reduction would be disproportionately broad
This novel tool, termed the Spearmans-Pearsons Decider, which expedited the processes needed to decide between a parametric or non-parametric analysis, is freely available at GitHub ( script and ReadMe in Supplementary Materials Scripts .zip file under Spearmans_Pearsons_Decider and ReadMe for Spearmans_Pearsons_Decider, respectively)
Ethics declarations Competing interests MCM: Bayer (consultant), Roche (consultant, speaker), and SJJ Solutions (consultant, royalties, speaker)
