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The expected glucose-lowering efficacy is an important consideration when changing from one glucose-lowering agent to another or when adding a new agent to existing therapy

In addition, the FoxO4/ectonucleotide pyrophosphatase/phosphodiesterase family member 2 axis and the TRIM21/NRF2 axis can inhibit ferroptosis, thereby alleviating doxorubicin-induced cardiotoxicity

Accessed Mar 27, 2025

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FAs can increase the de novo synthesis of HIF-1 at the translational level through fatty acid-binding protein 5 (FABP5) (105), and in GA models, the FA-induced significant upregulation of acyl-CoA synthase long-chain family member 1 (ACSL1) and CPT1A-promoted FA -oxidation together activate HIF-1 in the liver cells (106)

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