Some formulations bundle fenugreek, fructooligosaccharides, and various plant compounds, promoting them as 'natural GLP-1 alternatives.' Marketing images and testimonials often obscure the fact that these supplements have not been tested against semaglutide in head-to-head trials
(Eur J Endocrinol 1998) reported that ipamorelin stimulated GH release from anterior pituitary somatotrophs via GHSR-1a (Gq/11PLCIP pathway) at doses up to 200-fold its GH-effective dose without significantly elevating ACTH, cortisol, FSH, LH, prolactin, or TSH above GHRH-stimulated controls in rats
Of course its not just about calories
Soft Matter 10 , 43604372 (2014) M
Long-Term Value of Semaglutide Semaglutide offers significant long-term value by providing sustained weight loss, improving metabolic health (blood sugar, cholesterol, blood pressure), reducing cardiovascular events (heart attack, stroke), and enhancing overall quality of life (energy, mobility, mood)
Among the nutraceuticals most investigated as single agents, yohimbine has been used for over several decades as a therapeutic option for ED [21], being particularly successful in patients with non-organic forms [22], whereas Korean red ginseng has been suggested to improve ED, although with less firm evidence [23]