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IQVIAs analysis of IRA commercial impact shows that the net present value of a small-molecule drugs commercial opportunity declines by an estimated 40 to 60 percent relative to the pre-IRA environment, depending on indication, Medicare share of revenues, and time to negotiation eligibility

Studies have shown that patients with HS exhibit decreased levels of the anti-inflammatory adipokine adiponectin and increased levels of leptin, resistin, and visfatin compared to healthy individuals

Zinovkin et al., 2014)

Zepbound and Mounjaro have the same titration schedule and dose strengths, but their FDA-approved indications differ: Zepbound for chronic weight management and Mounjaro for type 2 diabetes

A numbing cream is used to minimise discomfort, and most people find the treatment manageable