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Kisspeptin is a reproductive-signalling peptide

Higher ("pharmacologic") doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above normal ("physiologic")

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AOD-9604 originated from research at Monash University in the 1990s seeking to isolate the lipolytic domain of human growth hormone from its growth-promoting and metabolic-side-effect domains

This occurs because the underlying biological drivers of obesity, hormonal setpoints, metabolic adaptation, and appetite regulation, reassert themselves once the pharmacological intervention is removed

In genetically obese Zucker rats and ob/ob mice, AOD-9604 reduced body weight without affecting glycemic control, unlike growth hormone