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The company said that the trial "achieved its primary endpoint of non-inferiority for the composite cardiovascular (CV) endpoint." Merck announced only one additional detail: "Among secondary endpoints," they reported, "there was no increase in hospitalization for heart failure in the sitagliptin group versus placebo." The FDA has been wrestling for a number of years now with the problem of the cardiovascular effects-- whether positive or negative-- of diabetes drugs

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The log-rank test was used to compare overall survival among these groups

Accessed October 17, 2025