The only difference is the FDA-approved indication (type 2 diabetes versus chronic weight management)
The addition of glucagon receptor agonism has, in early-phase studies, been associated with increased energy expenditure and potential effects on fat stored in the liver
Persistent cravings for sweets, processed foods, and high-calorie snacks
Some GLP-1 injections come pre-filled as easy-to-use pens (like an EpiPen), while others come as vials and separate syringes that you must measure yourself
To illustrate how storage requirements vary between licensed peptide medicines, and why extrapolation is unreliable: Semaglutide (Ozempic, Wegovy) according to the respective Summaries of Product Characteristics (SmPCs) on the Electronic Medicines Compendium (EMC), these products may be stored below 30C for a defined period after first use, but conditions differ between formulations Liraglutide (Saxenda) the SmPC specifies a different room-temperature allowance and duration Tirzepatide (Mounjaro) a dual GIP/GLP-1 agonist with its own distinct storage instructions [11] [12] These examples demonstrate that even closely related agents have product-specific requirements that cannot be applied to retatrutide
Based on the available data, tirzepatide has the lowest discontinuation rates and similar or slightly lower GI side effect rates compared to semaglutide
