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Compounded GLP-1 optionsincluding compounded semaglutide from licensed 503A pharmaciesoffer an alternative when branded medications face coverage barriers
Review describing the physiological role of GLP-1 in the central regulation of feeding behaviour, as well the effects of pharmacological stimulation of GLP-1 pathways leading to alterations in CNS activity, reduced food intake and weight loss in obesity and T2DM
Sig Transduct Target Ther 5 , 231 (2020)
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DOI:10.1097/MPG.0000000000001179 31
Patients had type 2 diabetes with NO other anti-diabetic agents allowed for at least 90 days prior to the trial
PROTAC-based approaches have been developed to selectively degrade aggregation-prone proteins, including QC-01-C175 for tau in AD, XL01126 for LRRK2 in PD, and GW5074 for mutant huntingtin in HD
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