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Nature 402:685689 Rubi B, Ishihara H, Hegardt FG, Wollheim CB, Maechler P (2001) GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells

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While not a direct side effect, some patients may experience musculoskeletal pain, which can include back pain, possibly due to weight loss or changes in body composition

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Although the mutual node F583/F538 is not part of the binding site, it is specifically interesting since we previously reported that the point mutation F583A results in a long-range allosteric impact, that propagates across the membrane, rendering the protein inactive (Weigl et al., 2018

(PubMed) Lang A, Salomon N, Wu JC, et al