The enteric nervous system appears particularly vulnerable, and enteric -syn pathology often precedes motor symptoms, supporting the hypothesis that PD may originate in the gut and propagate to the brain in a transsynaptic prionlike manner [80]
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doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao
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