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Sulphur can be found in protein-rich foods like beef, fish and chicken, and there are vegetarian sources too, such as broccoli, leafy greens and cauliflower

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Accordingly, altered HSP expression has been implicated in the pathogenesis of multiple metabolic disorders, positioning HSPs as both biomarkers of disease severity and promising, albeit complex, therapeutic targets (Fig

Furthermore, chronic inflammation is recognized as a key factor in inducing insulin resistance, and GPER can modulate intracellular signaling pathways or suppress the expression of proinflammatory cytokines, which reduces the interference of chronic inflammatory responses and improves insulin resistance [1, 34]