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Tryptophan catabolism can also be initiated within non-hepatic tissues by the enzyme indoleamine 2,3-dioxygenase 1 encoded by the IDO1 gene

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doi: 10.3389/fphys.2022.1036515 31 ImaiHMatsuokaMKumagaiTSakamotoTKoumuraT

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It is administered intravenously or intramuscularly by a healthcare professional, with dosing tailored to the individual patients needs and clinical response

Previous research has shown that GPx1 is an effective antioxidant enzyme that cannot be replaced by any other selenoprotein to protect against generalized oxidative stress [74,75,76]