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Dual Agonists Under Investigation Tirzepatide (Mounjaro) was approved by the FDA on May 13, 2022 for the treatment of type 2 diabetes in adults, making it the first and only GIP/GLP-1 receptor agonist

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a biologically active form GLP-1-(736) amide and an inactive form GLP-1-(1-37)

"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky