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2) It is a prescription drug and we can only administer it on the day it is due

High-fat meals slow it further, increasing the time food sits in the stomach and amplifying nausea, bloating, and reflux

Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

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Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency

We will carry out a medical consultation and discuss potentially associated contraindications