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However, both drugs independently reduce appetite and fluid intake, creating an additive risk for dehydration, electrolyte imbalances, and acute kidney injury in vulnerable populations

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In 2025, 52% of Americans said they would like to lose weight, according to a Gallup survey

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For non-oral dosage forms, public plans generally pay 75% to 85% of the brand price for the first generic, dropping to around 50% once a second product is listed and to roughly 35% when three or more generics are available

[1] DRIs are used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects, and in the treatment of obesity and binge eating disorder for their appetite suppressant effects