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Prevention and treatment of constipation are essential for the management of opioid treatment: the combination with prophylactic laxatives is recommended early, also before the opioid prescription

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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)

This is mechanism evidence, not outcome evidence

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