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Lack of expression of melanocytic markers (eg MelanA, HMB45, MITF) is very helpful in the distinction of epithelioid MPNST from melanoma and clear cell sarcoma

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Evaluation may include history, physical exam, inflammatory markers, autoimmune labs, metabolic assessment, and functional medicine testing when appropriate.

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Healthcare providers can assess injection technique, review site rotation practices, and consider whether alternative treatment options might be better tolerated