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He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II, Swisher SG , Pataer A

Gaur P, Hofstetter WL, Bekele BN, Correa AM, Mehran RJ, Rice DC, Roth JA, Vaporicyan AA, Rice TW, Swisher SG

Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis

Additionally, various types of cell death have been linked to IRI, including necroptosis, apoptosis, pyroptosis, and ferroptosis

Markers of synaptogenesis including dendritic spine density and synaptic protein expression remain elevated for 1014 days following administration, meaning a missed dose doesn't immediately reverse therapeutic effects

PMID: 27687306