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This action may contribute to improved metabolic health and other associated benefits

GLP-1 peptides commonly cause: Significant nausea : Often severe enough to require dose titration over months

Nature 2011 472(7341):40 - 41 M

So far, there are no published randomized, controlled trials investigating pharmacological treatment options for fluid intake in primary polydipsia

Individual factors including dose, frequency of use, urine pH, age, kidney function, and body composition all affect actual clearance times

[18] Systemic side effects may include headache, irritability, restlessness, depression, fatigue, or edema resulting from fluid retention