The cardiovascular benefits of GLP-1RAs are well-established, with clinical trials demonstrating reductions in major adverse cardiovascular events (MACE), improved endothelial function, and lower blood pressure
On average, volunteers in the retatrutide clinical trial who received the study drug rather than a placebo lost an average of 70.3 pounds over about a year-and-a-half, with more than 45% of participants losing more than 30% of their body weight
The entire plant including the leaves, stems, and flowers is used to make chanca piedra supplements
WLP-1 isn't a fast-acting stimulant
However, in evolutionary context it makes sense, as Met-derived GSLs are a later invention in plant evolution (both in comparison to other types of GSL and other types of secondary metabolites), and during evolution plants made use of already existing transporters from primary metabolism
Zhao Z, Li J, Zheng B et al (2020) Ameliorative effects and mechanism of crocetin in arsenic trioxide-induced cardiotoxicity in rats