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However, while these caspases were found to be functionally active in in vitro experiments, they were not activated by a variety of proapoptotic stimuli, indicating a unique regulation of apoptosis in RBCs

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This study provides evidence that exposure of isolated fresh erythrocytes for 24 h to CSE induces eryptosis by p38 MAPK-initiated DISC formation, followed by activation of caspase-8/caspase-3 via ceramide formation by neutral SMase

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