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In a multicentre pooled analysis of 531 patients with metastatic NSCLC treated with Nivolumab as a second line therapy, 33.0% (173 patients) developed irAEs and had a significantly longer OS (14.9 versus 7.4 months

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The addition of semaglutide to this already high-risk group showed further b12 decline, but whether this represents a medication effect, dietary changes from additional appetite suppression, or natural progression of post-surgical deficiency remains unclear

Sources: Hsieh MJ, Liu HT, Wang CN, et al

As in the entire cohort, there were no significant changes in half-life or pulse frequency (Table 2)

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