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Months of lower body weight produce lasting benefits including improved insulin sensitivity, reduced hepatic fat, decreased inflammatory markers, and potentially improved cardiovascular remodeling

Anti-emetic medications are generally not recommended as first-line treatment, as most nausea resolves with dietary adjustments and time

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Dulaglutide is not indicated in the treatment of subjects with type 1 diabetes or patients with diabetic ketoacidosis because these problems are the result of the islet cells being unable to produce insulin and one of the actions of dulaglutide is to stimulate functioning islet cells to produce more insulin

Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al

Some also notice subtle changes in appetite, which is an early sign that semaglutide is engaging hungerregulating pathways