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Given that the IC 100 concentration of niclosamide required to completely prevent viral replication in SARS-CoV-2 infected Calu-3 lung cells as measured by Ko et al (34) as 2M, a 20uM niclosamide solution nasal spray is 10x this IC 100

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Pharmacodynamic Considerations: Overlapping Biology, Not Opposing Effects Where the interaction picture becomes more nuanced is at the pharmacodynamic level

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