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Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics

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These pathways regulate neurogenesis, angiogenesis (new blood vessel formation), myelination, dendrite development, axonal sprouting, and the integrity of the neurovascular unit the critical connection between brain cells and blood supply