[15] [16] In the brain, GLP-1 receptor activation has been linked with neurotrophic effects including neurogenesis [17] [18] and neuroprotective effects including reduced necrotic [19] and apoptotic [20] [19] signaling, cell death, [21] [22] and dysfunctions
doi:10.3390/nu11112611 Shi Q, Nong K, Vandvik PO, et al
Thats why GLP-1 medications werent designed as a one-time solution
Both tirzepatide and retatrutide use gradual dose escalation strategies to minimize gastrointestinal side effects, but their specific protocols differ in ways that affect the practical experience of using each compound
While GLP-1 receptors exist in brain regions associated with mood and reward, serious mood disturbances are uncommon and should be reported to a provider if they occur
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