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99102 Insulin sensitivity and glucose metabolism Insulin resistance is a key pathophysiological feature of MASLD, 10 and SIRT1 plays a central role in regulating insulin signaling and hepatic glucose metabolism

Researchers said weight regain has been reported after stopping other obesity medications, and overall data confirm the chronicity of obesity and highlight the importance of maintaining long-term pharmacological treatment for weight management in people with obesity. The success of GLP-1 medications can depend on how long people use them

Ahn JH, Cho H, Kim JH, et al

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In a clinical trial with 2,519 patients, Zepbound (tirzepatide) was taken at doses of 5 mg, 10 mg, and 15 mg over a 72-week period, with an additional 958 people receiving a placebo

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