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Established pharmacological options including acamprosate, naltrexone, and nalmefene remain the evidence-based first-line treatments

Additionally, inflammation limits the usefulness of plasma/serum testing

For example, LSD1 and CARM1 modulate both histone and nonhistone proteins, indicating that epigenetic control operates at multiple regulatory levels

(2014) 6:a016295

Not a substitute for the surgical option in cases of significant loose skin where surgery is indicated

For patients who have already lost weight but still struggle with stubborn belly fat that will not respond to diet and exercise alone, fat reduction and body sculpting treatments can target specific problem areas