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Data availability No new datasets were analyzed or generated in this review article
Mean HbA1c (%) over time - baseline to week 56 Combination with metformin or metformin with sulfonylurea In a 56-week, open-label trial (NCT01885208), 813 patients with type 2 diabetes mellitus on metformin alone (49%), metformin with sulfonylurea (45%), or other (6%) were randomized to OZEMPIC 1 mg once weekly or exenatide 2 mg once weekly
While these medications are also effective for weight loss, Zepbounds additional mechanism of action through GIP may offer enhanced benefits for certain individuals
The results showed a significant statistical correlation between DPP-4 inhibitors and AEs related to biliary diseases, while GLP-1 RAs exhibited strong signal intensity, suggesting a possible association with biliary diseases
