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Yes, body weight is a significant factor

Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study

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In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]