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Another function of carnitine in human metabolism is its involvement in the detoxification process of toxic compounds (such as some foreign substances, including ampicillin, valproic acid, and salicylic acid, as well as toxic substances generated endogenously via metabolism), which are jointly excreted by the kidneys with carnitine (82)

The K m value for CDNB was obtained by reacting 0.5 g of purified e-GSTs of mammals with variable amounts of CDNB (from 0.05 to 2 mM) in the presence of 1 mM GSH, in 0.1 M potassium phosphate buffer, pH 6.5 (25 C)

10.1124/pharmrev.120.000096 169 YamauchiM.KitamuraY.NaganoH.KawatsuJ.GotohH

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