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However, further research is needed to fully understand the molecular mechanisms underlying its actions

Isogenic mutants deficient in the activities of thioredoxin (54), catalase (KatA) (55), NADPH quinone reductase (56), and superoxide dismutase (46) are sensitive to host colonization and susceptible to oxidative damage

[3] Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D

It was first isolated and studied by Predrag Sikiric and colleagues at the University of Zagreb, whose group has authored the majority of published animal research on this compound over several decades

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Combination of CTLA-4 and PD-1 blockers for treatment of cancer