Clinical Implications of ALA ALA has been used in clinical practice for 70 years to alleviate symptoms associated with various diseases, including neurodegenerative disorders, diabetes, cancer, age-related cardiovascular issues, neuromuscular conditions, weight gain caused by antipsychotic medications, and metabolic obesity [1,8,15]
The effects appear to rely on GLP-1Rs located in the NAc shell and lateral septum, supporting the notion of region-specific neuromodulation
This dosing flexibility is an important consideration in the Mounjaro vs Trulicity decision
Clinical trials have shown that patients using Mounjaro can lose up to 22.5% of their body weight, compared to about 15% with Ozempic at maximum doses
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Stienstra, R