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We used the I 2 test and chi-square test to formally check for the presence of heterogeneity

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Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction

The addition of B12 may reduce severity, though individual responses vary

This incretin hormone plays several crucial roles in metabolic health: Stimulates insulin secretion from the pancreas in a glucose-dependent manner Suppresses glucagon release (which helps prevent blood sugar spikes) Slows gastric emptying, promoting longer feelings of fullness Reduces appetite by acting on brain centers that control hunger Improves beta-cell function in the pancreas The natural GLP-1 hormone has a very short half-life (12 minutes) in the bloodstream because it is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4)

Reads were aligned to the mouse GRCm38 genome using STAR v.2.5.2b