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Theoretical concerns include angiogenesis-related risk in patients with current or prior cancer, and effects on nitric oxide signaling that could matter for blood pressure

Having said that some patients do get a paradoxical response to B12 and present with fatigue, headaches, and flu-like symptoms

Additionally, B12 injections help maintain healthy nerve cells and red blood cells, which are crucial for overall vitality and well-being

However, this varies depending on weight, metabolism, and food intake

Signs suggesting adequate treatment include plateau in improvement for two or more weeks, significant resolution of primary concerns, and strong improvement maintained during previous breaks

Research shows Tesofensine can influence appetite quickly, but the timing varies between animal and human studies