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Hydrocortisone is metabolised to 6-beta hydrocortisol via CYP3A, 5-beta tetrahydrocortisol via 3-oxo-5-beta-steroid 4-dehydrogenase, 5-alpha tetrahydrocortisol via 3-oxo-5-alpha-steroid 4-dehydrogenase 2, cortisone via Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticosteroid 11-beta-dehydrogenase isozyme 2, and glucuronide products

The effects vary depending on individual needs, but the overall results are positive and consistent

This is one of three daily application windows

doi: 10.1182/BLOODADVANCES.2021006944 98 BesnierFBrubBMaloJGagnonCGrgoire Ca JuneauMet al

We refer readers to the CY 2026 OPPS/ASC proposed rule (80 FR 33770 through 33771) for further discussion of the measure's review and evaluation