Coskun and Urva (2022, pharmacological description) describe the engineering: modified sequence derived from native GIP, Aib2 and Aib13 substitutions resisting DPP-4, and a C20 diacid fatty-acyl chain grafted to a lysine via a gamma-glutamate linker to extend half-life to approximately 6 days
In older individuals, age-related changes in hepatic and renal functioning, cognitive functioning, presence of various comorbidities, administration of different drugs, and pharmacokinetics can potentially affect drug-drug interactions and exacerbate underlying medical conditions leading to side effects
Direct association of adenosine deaminase with a T cell activation antigen, CD26
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Effects of an SGLT inhibitor on the production, toxicity, and elimination of gut-derived uremic toxins: a call for additional evidence
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