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Chemotherapy can also induce senescence

This effect is achieved by the increased ROS formation (prooxidant effect), resulting in caspase 8 cleavage, inhibition of Janus kinase 2 (JAK2), and triggering regulator of apoptosis BAX, known as bcl-2-like protein 4

Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes