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56,57 The pathophysiological significance of this reaction to APAP is still controversial

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Population and duration

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d ) Bar plot showing the total number of TH+ positive cells that do not colocalize with EBF3 ( Trkb Penk-WT , 66.5 5.3 vs Trkb Penk-KO , 71 5.0

In these individuals it would appear that whilst they were able to exist as relatively healthy individuals, often not knowing that they had methylation associated mutations, some initiating factor such as a prolonged infection, combined with low vitamin D levels resulted in gradual loss of their vitamin B12 supplies leading to the CFS symptomatology being apparent, and the subsequent discovery of their methylation status