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The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that fuel the adverse metabolic phenotype

The reduction in oestrogen typically causes a redistribution of adipose tissue from peripheral sites (hips and thighs) to central abdominal areas, increasing visceral fat accumulation

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Opioids illustrate this dynamic

I spent over 4 decades in biopharma mainly around scientific regulatory strategy etc.

Strengthening the glutathione system supports all three phases of detoxification, but in particular phases II and III11