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IV delivery is generally considered the most bioavailable method and is preferred for patients seeking faster systemic effect
In the following excerpt, Derek talks to David Ricks about the genesis and evolution of GLP-1 drugs
Mechanistically, acetyl-CoA, a derivative of BCKAs, inhibits the interaction between PR domain-containing protein 16 (PRDM16) and peroxisome proliferator-activated receptor- (PPAR-) by acetylating the k915 site of PRDM16 to maintain WAT characteristics
doi: 10.1016/j.arr.2023.102066
However, for drugs that are primarily or exclusively used for orphan indications, it can be the dominant form of exclusivity
Irani K: Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
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