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The color change is typically temporary and harmless

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Clinical trials show that they are helpful for some people with POTS.[ref] The ADRB2 gene codes for the beta2-adrenergic receptor and the SLC6A2 gene encodes the norepinephrine transporter

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It targets two appetite hormones instead of one, producing more weight loss in clinical trials: 22.5% of body weight over 72 weeks

doi: 10.3390/ijms222413205