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Women with HbA1c above 86 mmol/mol (10%) should avoid pregnancy until diabetes control improves due to very high complication risks

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Cognitive Impairment: Many individuals with anhedonia struggle with insomnia or hypersomnia

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Binding of mipomersen to ApoB-100 mRNA activates RNase H, which cleaves the RNA and prevents ApoB-100 protein synthesis, thereby lowering circulating ApoB levels 112

Additionally, many of the currently available clinical agents display the always on characteristic, where they illuminate disease sites through self-accumulation rather than being specifically activated by target molecules of interest, which leads to poor imaging contrast and compromised detection accuracy