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Observed RHR Increases in Clinical Data: + Liraglutide (1.8 mg daily): +610 bpm + Semaglutide (1.02.4 mg weekly): +24 bpm + Tirzepatide (515 mg weekly): +1.53.5 bpm + Exenatide (5-10 g Twice daily): +23 bpm A meta-analysis of over 60 randomized clinical trials found the mean RHR increase with GLP-1RAs to be 2.11 bpm (95% CI: 1.682.54)

Evaluate performance based on established benchmarks

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Physical activity burns calories, preserves muscle mass, improves insulin sensitivity, and provides psychological benefits that reduce stress eating

Therefore, the metabolic benefits associated with RYGB are not uniformly significant [22]

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