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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

People taking the highest dose (12 mg) lost an average of 71 pounds over 16 months, starting from an average weight of about 249 pounds

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