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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

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Several underlying mechanisms may contribute: Enzyme deficiencies Particularly sulphite oxidase (SUOX) , which converts toxic sulphites into harmless sulphates

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Regulating cellular iron homeostasis after SCI by chelating excess iron ions and modulating iron transport pathways can promote the differentiation of neural stem/progenitor cells into neurons and stimulate the regenerative potential of newborn neurons, accompanied by improvements in axonal reinnervation and myelin regeneration

In these two studies we analyzed the interaction of 25HC with v3 integrin, as v3 integrin interacts with 25HC (Fig