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Meanwhile, in our opinion, programmed cell death, particularly apoptosis, could be added to this axis because the mechanisms of apoptosis and other forms of programmed cell death are inextricably linked to the mitochondria, mTOR, and autophagy

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Animal studies have shown that adult mammalian heart cells can be boosted to renew themselves through interventions like regulating transcription factors, stimulating specific microRNA pathways, exposing them to low oxygen conditions, or activating certain growth factor signaling pathways (Garbern and Lee 2022)

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