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10.1016/j.drudis.2020.12.004 27 BianchiV

doi: 10.1001/jamanetworkopen.2024.15455

High extracellular concentrations of glutamate, another raw material for glutathione synthesis, can inhibit system ( SLC7A11 ) and induce iron-dependent non-apoptotic cell death, which may explain the toxic effect of excessive glutamate accumulation in the nervous system (Yang and Stockwell, 2016

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