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Over time, mutated mtDNA molecules can undergo clonal expansion, and once the mutational burden exceeds a critical thresholdtypically 60% and 90% they produce a biochemical defect in OXPHOS, a concept referred to as the mtDNA mutational load (112)
These emerging therapeutic intervention strategies provide new strategies for regulating ROS levels and hold promise for playing important roles in the treatment of cancer and other diseases
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