Promising local administration mechanisms have been developed for RSL3 80 , but the current lack of systemic effect renders RSL3 and other GPX4 inhibitors ineffective for targeting metastases or difficult-to-access tumor sites for the moment
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To check if the drop in tumor cysteine levels was responsible for the tumor reduction, we repeated the experiment but we now supplemented the mice with N-acetyl-cysteine, which partially reversed the effect of the GGT inhibitor
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